Hollow-Core Optical Fiber Optofluidic DNA Sensor Based on Whispering Gallery Mode

Citation

张洪鑫, 李雪刚, 周雪, 张亚男, 赵勇. (2024). 基于回音壁模式的空芯光纤光流控DNA传感器 [Hollow-Core Optical Fiber Optofluidic DNA Sensor Based on Whispering Gallery Mode]. 光学学报 [Acta Optica Sinica], 44(9), 58-62.

Keywords

• Optical fiber sensor
• Optofluidic optical fiber sensor
• Hollow-core fiber (HCF)
• Whispering gallery mode (WGM)
• DNA sensor
• In-situ DNA sensing
• Label-free detection
• Microfluidic channel
• Tapered optical fiber
• Resonant cavity
• Refractive index sensitivity
• DNA hybridization
• Probe DNA (pDNA)
• Complementary DNA (cDNA)
• Concentration gradient detection

Brief

The article presents a highly sensitive and specific hollow-core optical fiber optofluidic sensor based on the whispering gallery mode (WGM) for label-free in-situ DNA detection by observing spectral shifts caused by DNA hybridization within its microfluidic channel.

Summary

Researchers developed a highly sensitive and specific hollow-core optical fiber sensor using whispering gallery mode (WGM) in a microfluidic channel to achieve label-free, in-situ detection of DNA hybridization by observing spectral shifts. The sensor exhibited a linear detection range of 10-100 nmol/L and a sensitivity of 0.56 pm/(nmol/L) with good stability and specificity, suggesting potential for medical diagnostics.

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