Smart-phone based computational microscopy using multi-frame contact imaging on a fiber-optic array

Smart-phone based computational microscopy using multi-frame contact imaging on a fiber-optic array

Citation

Navruz I, Coskun AF, Wong J, Mohammad S, Tseng D, Nagi R, Phillips S, Ozcan A. Smart-phone based computational microscopy using multi-frame contact imaging on a fiber-optic array. Lab Chip. 2013 Oct 21;13(20):4015-23. doi: 10.1039/c3lc50589h. Epub 2013 Aug 12. PMID: 23934060; PMCID: PMC516183. 

Keywords

  • Contact Scope
  • Computational Microscopy
  • Fiber-Optic Array
  • Multi-Frame Imaging
  • Shift-and-Add Algorithm
  • Transmission Mode
  • Cellphone-Based
  • Resolution Enhancement
  • Blood Smear Imaging
  • Telemedicine Applications 

Brief

Contact Scope is a computational microscope that captures magnified images of highly dense samples using a smartphone camera and a rotating fiber-optic array. This portable microscope weighs approximately 76 grams and functions by using a shift-and-add algorithm to merge multiple images of a sample taken at different angles, resulting in a high-resolution microscopic image.

Summary

This paper describes Contact Scope, a computational microscope add-on for cellphones that uses a tapered fiber-optic array to capture magnified images of samples in contact with its surface. The device and accompanying Android application digitally combine multiple images taken at different angles of the fiber optic array, enhancing the resolution of the final image. Testing demonstrated Contact Scope's ability to image samples like blood smears with a resolution of >1.5-2.5 μm over a field of view of >1.5-15 mm2. This makes it a promising tool for telemedicine applications, especially in resource-limited settings.

Origin: https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3804724&blobtype=pdf

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