Analysis of differential gene expression by bead-based fiber-optic array in growth-hormone-secreting pituitary adenomas

Citation

JianG Z, Gui S, ZhanG Y. Analysis of differential gene expression by bead-based fiber-optic array in growth-hormone-secreting pituitary adenomas. Exp Ther Med [serial online]. August 2010;1(5):905-913. doi:10.3892/etm.2010.137

Keywords

  • Growth-hormone-secreting pituitary adenomas
  • Ghomas
  • gene expression
  • bead-based fiber-optic array
  • qRT-PCR
  • pathway analysis
  • Wnt signaling pathway
  • ECM-receptor interactions
  • HIGD1B
  • HOXB2
  • ANGPT2
  • HPGD
  • BTG2

Brief

Bead-based fiber-optic array analysis, confirmed by qRT-PCR, identified numerous aberrantly expressed genes, such as HIGD1B, HOXB2, ANGPT2, HPGD and BTG2, and pathways, including Wnt signaling and ECM-receptor interactions, that may be involved in the pathogenesis of growth-hormone-secreting pituitary adenomas (GHomas).

Summary

This article, published in 2010, explores the pathogenesis of growth-hormone-secreting pituitary adenomas (GHomas). The authors, JianG, Gui, and ZhanG, utilized bead-based fiber-optic arrays to examine gene expression in GHomas compared to healthy pituitary tissues.

Key Findings:

  • Array analysis revealed significant expression changes in numerous genes and expressed sequence tags (ESTs).
  • HIGD1B, HOXB2, ANGPT2, HPGD, and BTG2 were identified as potential key players in GHoma development and progression.
  • Pathway analysis highlighted the Wnt signaling pathway and extracellular-matrix receptor interactions as potentially significant in GHoma pathogenesis.

The authors concluded that this approach is valid for investigating tumor pathogenesis. They suggest that further research into the identified genes and pathways could enhance our understanding of GHomas.

Origin: https://www.spandidos-publications.com/10.3892/etm.2010.137

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