Label-Free Detection of Cancer Biomarkers Using an In-Line Taper Fiber-Optic Interferometer and a Fiber Bragg Grating

Citation

Sun, D.; Ran, Y.; Wang, G. Label-Free Detection of Cancer Biomarkers Using an In-Line Taper Fiber-Optic Interferometer and a Fiber Bragg Grating. Sensors 2017, 17, 2559.

Keywords

  • fiber taper interferometer
  • FBG
  • optical biosensor
  • cancer biomarker

Brief

A compact and label-free optical fiber sensor was demonstrated for the detection of HER2, a breast cancer biomarker.

Summary

The article presents a new optical fiber sensor for detecting the breast cancer biomarker HER2. The sensor, which is compact and label-free, is based on a taper interferometer and a fiber Bragg grating (FBG). The taper interferometer is highly sensitive to changes in refractive index (RI), which occur when the biomarker is present. The FBG, on the other hand, is insensitive to RI changes and serves as a temperature thermometer to ensure accurate measurements.
Here are the key takeaways from the article:
  • High sensitivity: The sensor can detect HER2 at concentrations as low as 2 ng/mL.
  • Specificity: The sensor is designed to specifically target the HER2 biomarker.
  • Real-time monitoring: The sensor can provide real-time information about the presence and concentration of HER2.
  • Early diagnosis potential: The high sensitivity and specificity of the sensor make it a promising tool for the early diagnosis of breast cancer.

Origin: https://www.semanticscholar.org/reader/8899ec56d205942dceaa86a7207c5456a38bf6eb

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