Antimonene-Coated Uniform-Waist Tapered Fiber Optic Surface Plasmon Resonance Biosensor for the Detection of Cancerous Cells: Design and Optimization

Antimonene-Coated Uniform-Waist Tapered Fiber Optic Surface Plasmon Resonance Biosensor for the Detection of Cancerous Cells: Design and Optimization

Citation

Vikas & Saccomandi, P. Antimonene-Coated Uniform-Waist Tapered Fiber Optic Surface Plasmon Resonance Biosensor for the Detection of Cancerous Cells: Design and Optimization. ACS Omega, 2023, 8, 4627−4638.

Keywords

  • Antimonene-coated
  • Uniform-waist tapered
  • Fiber optic
  • Surface plasmon resonance (SPR)
  • Biosensor
  • Cancerous cells
  • Sensitivity
  • Detection accuracy (DA)
  • Figure of merit (FOM)
  • Limit of detection (LOD)
  • Graphene
  • Gold (Au)
  • Refractive index (RI)
  • Sensing medium refractive index (SMRI)
  • Taper ratio (TR)
  • Resonance wavelength (RW)

Brief

A novel graphene-antimonene-coated uniform-waist tapered fiber optic surface plasmon resonance biosensor is demonstrated for the early-stage detection of cancerous cells.

Summary

This article presents a novel design for a biosensor that can detect different types of cancerous cells. The biosensor utilizes a graphene-antimonene coating on a uniform-waist tapered fiber optic surface plasmon resonance (SPR) structure. Antimonene enhances the sensor’s performance because of its strong binding energy with biomolecules and large active surface area. The sensor is designed and analyzed using a transfer matrix method-based simulation platform.
Here are the key findings of the study:
The biosensor demonstrated a high sensitivity to refractive index (RI) variations, outperforming other sensors across a wide range of RIs, including those found in biological solutions.
The sensor effectively detects various cancerous cells in the human body, specifically those with RIs ranging from 1.36 to 1.4.
The study analyzed the impact of the taper ratio on the sensor's performance.
Researchers assessed the performance of the SPR biosensor using metrics such as:
Sensitivity: Measured how effectively the sensor detected changes in RI.
Full width at half maximum (FWHM): Indicated the sensor’s ability to differentiate between different RI values.
Detection accuracy (DA): Evaluated the sensor’s accuracy in identifying target analytes.
Figure of merit (FOM): Provided a comprehensive measure of the sensor’s overall performance.
Limit of detection (LOD): Determined the smallest detectable change in analyte concentration.
Numerical results indicated that the designed sensor achieved a remarkable sensitivity, ranging from 7.3465 to 15.2414 μm/RIU, for detecting various types of cancer, including:
  • Skin cancer
  • Cervical cancer
  • Blood cancer
  • Adrenal gland cancer

The sensor also exhibited a maximum FOM of 131.1525 RIU−1, a DA of 14.2126 μm−1, and an LOD of 7.2 × 10−5 RIU.
The authors concluded that this SPR sensor has the potential for early-stage cancer diagnosis and holds promise for advancements in biosensing technology.

Origin: https://pubs.acs.org/doi/pdf/10.1021/acsomega.2c06037

 

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