Fiber-optic array using molecularly imprinted microspheres for antibiotic analysis
Citation
The full citation for the article is Carrasco, S., Benito-Peña, E., Walt, D.R., & Moreno-Bondi, M.C. (2015). Fiber-optic array using molecularly imprinted microspheres for antibiotic analysis. Chem. Sci., 6, 3139.
You can find this information on the second page of the document. Additionally, the article was received on January 12, 2015 and accepted on March 18, 2015.
Keywords
- Molecularly Imprinted Polymers (MIPs)
- Microarrays
- Fiber-optic
- Enrofloxacin (ENRO)
- BODIFLOXACIN
- Antibiotic Analysis
- Multiplexed Detection
- Sheep Serum
Brief
A new high-density optical microarray using molecularly imprinted microsphere sensors with specific recognition capabilities can detect enrofloxacin, an antibiotic. This new class of microarrays uses highly cross-linked polymer microspheres that are fluorescently encoded.
Summary
Researchers developed a new fiber-optic microarray for detecting the antibiotic enrofloxacin (ENRO) in sheep serum. The microarray uses molecularly imprinted polymer (MIP) microspheres that specifically bind to ENRO. The MIPs are paired with a fluorescent analogue of ENRO, BODIFLOXACIN. When the microarray is exposed to a sample, BODIFLOXACIN competes with ENRO for binding sites on the MIP microspheres. The resulting change in fluorescence is used to determine the ENRO concentration.